Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NADH powder efficacy in health
Improved energy levels
Not only does NADH act as an important coenzyme in aerobic respiration, the [H] of NADH also carries a large amount of energy. Studies have demonstrated that extracellular use of NADH promotes increased intracellular ATP levels, suggesting that NADH penetrates cell membranes and elevates intracellular energy levels. On a macro level, exogenous supplementation of NADH helps to restore energy and enhance appetite. The increase in energy levels in the brain also helps to improve mental performance and sleep quality. NADH has been used overseas to improve chronic fatigue syndrome, increase exercise endurance, jet lag and other areas.
Cellular protection
NADH is a strong antioxidant that naturally occurs in cells and reacts with free radicals to inhibit lipid peroxidation, protecting mitochondrial membranes and mitochondrial function. It has been found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise and ischemia, thus protecting vascular endothelial cells, hepatocytes, cardiomyocytes, fibroblasts and neurons. Therefore, injectable or oral NADH is used clinically to improve cardiovascular and cerebrovascular diseases, and as an adjunct to cancer radiotherapy. Topical NADH has been shown to be effective in the treatment of rosacea and contact dermatitis.
Promotion of neurotransmitter production
Studies have shown that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal that is essential for short-term memory, involuntary movements, muscle tone and spontaneous physical responses. It also mediates the release of growth hormone and determines muscle movement. Without sufficient dopamine, muscles become stiff. Parkinson's disease, for example, is caused in part by a disruption of dopamine synthesis in brain cells. Preliminary clinical data suggest that NADH can help improve the symptoms of Parkinson's disease [9]. NADH also promotes the biosynthesis of norepinephrine and serotonin, showing good potential for use in the relief of depression and Alzheimer's disease.
NADH powder manufacturing method
The main methods of NADH powder preparation include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme become the mainstream method owing to the advantages of pollution free, high level of purity and stability.
BONTAC NADH product features and advantages
1、“Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder
2、Exclusive“Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NADH powder
3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder
4、Provide one-stop product solution customization service
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Frequently Asked Question
Do you have any question?
NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes
First, inspect the factory. After some screening, NADH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NADH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NADH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
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Hi & Fi Asia-China 2022
The 23rd Healthy Natural Raw materials, food ingredients China Exhibition opened in Shanghai National Convention and Exhibition Center Bangtai Biological with the third generation of total enzyme catalytic technology C position debut to carry out a three-day total enzyme catalytic high purity NMN raw materials debut tour booth number: 41H40. Hi & Fi Asia-China
Tight Connection of NADP+/NADPH Balance with Cardiovascular Pathologies
Introduction Cardiovascular diseases (CVD) poses huge economic burden and great threat to the life of patients, even surpassing Alzheimer's disease and diabetes. 17.9 million people in the world die from CVD, with indirect treatment costs of $237 billion per year, which are projected to increase to $368 billion by 2035. It has been reported that the deficiency or imbalance of oxidized nicotinamide adenine dinucleotide phosphate (NADP+)/reduced nicotinamide adenine dinucleotide phosphate (NADPH) redox couple has been linked to a variety of pathological conditions including CVD. NADP(H) redox couple as cofactor/electron carrier in cardiommyocytes NADPH is an essential cofactor of glutathione reductase (GR) and thioredoxin reductase (TRs) in cardiommyocytes, with a crucial role in maintaining cellular redox homeostasis and energy metabolism. GR catalyzes the recycling of Glutathion (GSH) from oxidized glutathione (GSSG), and TRs reduces oxidized Trx-S2 into Trx-(SH)2. Simultaneously, both enzymes require NADPH as an electron donor and oxidize it to NADP+. Once O2•− is formed, for example, from NOXs in the cytosol and from mitochondrial electron transport chain (ETC), cytosolic CuZnSOD and mitochondrial MnSOD will reduce it to H2O2. GSH can be used by glutathione peroxidase (GPx) to reduce H2O2 further to water. Trx-(SH)2 provides reducing equivalents for Prx in the removal of H2O2. The connection of NADP(H) with cardiovascular pathologies NADP(H) plays a dual role in cardiovascular pathologies. On the one hand, the reduced NADPH can result in significant antioxidant deficiencies and intracellular accumulation of free radicals, which triggers lipid peroxidation, inflammation, and vascular dysfunction, ultimately exacerbating the course of atherosclerosisoxidase. On the other hand, high NADPH level can give rise to myocardial injury by inducing reductive stress and enhancing reactive oxygen species (ROS) production. Conclusion Changes in cellular NADP(H) content affect the intermediary metabolism of cardiac function, especially in diseased myocardium. Maintaining the balance between NADP+ and NADPH in cardiommyocytes is critically important for the treatment of CVD. Either deficiency or excess NADP(H) levels can lead to imbalances in cellular redox state and metabolic homeostasis, resulting in energy stress, redox stress, and ultimately disease state. NADP(H) has an important therapeutic value in CVD. Reference Sun Y, Wu D, Hu Q. NADP+/NADPH in Metabolism and its Relation to Cardiovascular Pathologies. Curr Med Chem. Published online February 16, 2024. doi:10.2174/0109298673275187231121054541 BONTAC NADP(H) BONTAC has dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NADP(H). Bonzyme whole-enzymatic method is adopted, which is environmental-friendly, with no harmful solvent residues. The purity of NADP and NADPH can reach up to 95% and 98%, respectively, which is benefited from the exclusive Bonpure seven-step purification technology. BONTAC has self-owned factories and has obtained a number of international certifications, where high quality and stable supply of products can be ensured. BONTAC has four domestic and foreign NADPH patents, leading the industry. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
Elevating Wellness: BONTAC Advanced Raw Materials for Cellular Health Supplements
Elevating Wellness: BONTAC Advanced Raw Materials for Cellular Health Supplements In today's fast-paced world, the quest for optimal health and wellness has led to a surge in the demand for high-quality cellular health supplements. At BONTAC, we specialize in crafting advanced raw materials that cater to the intricate needs of cellular health, promoting vitality and resilience at the core level of the body. Cutting-Edge Formulations for Cellular Health At BONTAC, our team of experts dedicates itself to pushing the boundaries of cellular nourishment through innovative approaches and meticulous formula development processes. Our advanced formulations are designed to enhance cellular function, supporting overall well-being and longevity through targeted nutritional support. At BONTAC, we recognize that every person's metabolism-boosting journey is unique, and we strive to provide a diverse range of products that cater to a wide spectrum of needs and preferences. Whether it's supporting energy production, promoting efficient nutrient utilization, or enhancing metabolism-boosting flexibility, our comprehensive lineup of metabolism-boosting products is designed to empower individuals to take control of their metabolism-boosting well-being. Unlocking the Benefits of Cellular Health Supplements BONTAC raw materials for cellular health supplements are carefully crafted to strengthen cellular resilience, boost energy metabolism, and promote optimal cell function. By incorporating the latest scientific advancements, our products can fortify the body at the cellular level, offering a comprehensive approach to enhancing health and vitality. Partnering with BONTAC for Cellular Wellness Solutions When businesses partner with BONTAC, they gain access to tailored strategies for cellular health, backed by our expertise in the field. Our commitment to technical innovation ensures that our products continually evolve to meet the changing needs of our customers. Through collaboration with BONTAC, businesses can tap into our comprehensive business coverage and strengthen their health offerings with our advanced cellular health supplements. By choosing BONTAC's metabolism-boosting products, you are not only investing in your health but also aligning yourself with a company that is dedicated to advancing the field of metabolism-boosting science. With our unwavering commitment to quality, innovation, and customer satisfaction, we invite you to join us on this transformative journey towards optimal metabolism-boosting health and a vibrant, fulfilling life. Conclusion Embark on a transformative journey towards enhanced health and longevity with BONTAC state-of-the-art raw materials for cellular health supplements. Our commitment to excellence, technical support, and innovation sets us apart in the industry, ensuring that our products meet or even exceed the expectations of our partners and customers. Join us in optimizing cellular wellness and unlocking the full potential of health with BONTAC by your side. In conclusion, BONTAC advanced raw materials for cellular health supplements demonstrate our dedication to providing outstanding products that prioritize the well-being of our customers. If you require further information or assistance, please do not hesitate to reach out to our team.