Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NADH manufacturing method
The main methods of NADH powder preparation from worldwide NADH manufacturers include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme become the mainstream method owing to the advantages of pollution free, high level of purity and stability.
NADH powder efficacy in health
1.Improved energy levels
Not only does NADH act as an important coenzyme in aerobic respiration, the [H] of NADH also carries a large amount of energy. Studies have demonstrated that extracellular use of NADH promotes increased intracellular ATP levels, suggesting that NADH penetrates cell membranes and elevates intracellular energy levels. On a macro level, exogenous supplementation of NADH helps to restore energy and enhance appetite. The increase in energy levels in the brain also helps to improve mental performance and sleep quality. NADH has been used overseas to improve chronic fatigue syndrome, increase exercise endurance, jet lag and other areas.
2.Cellular protection
NADH is a strong antioxidant that naturally occurs in cells and reacts with free radicals to inhibit lipid peroxidation, protecting mitochondrial membranes and mitochondrial function. It has been found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise and ischemia, thus protecting vascular endothelial cells, hepatocytes, cardiomyocytes, fibroblasts and neurons. Therefore, injectable or oral NADH is used clinically to improve cardiovascular and cerebrovascular diseases, and as an adjunct to cancer radiotherapy. Topical NADH has been shown to be effective in the treatment of rosacea and contact dermatitis.
3.Promotion of neurotransmitter production
Studies have shown that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal that is essential for short-term memory, involuntary movements, muscle tone and spontaneous physical responses. It also mediates the release of growth hormone and determines muscle movement. Without sufficient dopamine, muscles become stiff. Parkinson's disease, for example, is caused in part by a disruption of dopamine synthesis in brain cells. Preliminary clinical data suggest that NADH can help improve the symptoms of Parkinson's disease [9]. NADH also promotes the biosynthesis of norepinephrine and serotonin, showing good potential for use in the relief of depression and Alzheimer's disease.
BONTAC NADH product features and advantages
1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder
2、Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NADH powder
3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder
4、Provide one-stop product solution customization service
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Frequently Asked Question
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1. Prevention and treatment of viral-induced inflammatory storms
Scientists have found after extensive research that neo-coronavirus has a mechanism similar to SARS virus to activate inflammatory vesicles NLRP3. and the activation of NLRP3 produces more inflammatory factors, generating excessive inflammation and thus triggering a deadly cytokine storm. This problem can be well addressed by NAD+, which inhibits the activity of NF-κB inflammatory pathway and NLRP3 inflammasome by increasing the activity of sirtuins (SIRT1, SIRT2 and SIRT3), thus preventing cytokine storm caused by excessive inflammation. Therefore, Sinclair and other scientists believe that increasing the concentration of NAD+ may play an important role in the prevention and treatment of neocoronavirus and other viral infections.
2. Restoration of virus-induced metabolic disorders
NAD+ is an essential coenzyme for many cellular energy metabolic pathways, present in every cell of the body, involved in thousands of reactions, and an important player in maintaining cellular viability. In the COVID-19 infection model, NAD+ and NMN supplementation was found to be effective in alleviating cell death and protecting the lung.
The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes
First, inspect the factory. After some screening, NADH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NADH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NADH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
Our updates and blog posts
Elevating Wellness: BONTAC Advanced Raw Materials for Cellular Health Supplements
Elevating Wellness: BONTAC Advanced Raw Materials for Cellular Health Supplements In today's fast-paced world, the quest for optimal health and wellness has led to a surge in the demand for high-quality cellular health supplements. At BONTAC, we specialize in crafting advanced raw materials that cater to the intricate needs of cellular health, promoting vitality and resilience at the core level of the body. Cutting-Edge Formulations for Cellular Health At BONTAC, our team of experts dedicates itself to pushing the boundaries of cellular nourishment through innovative approaches and meticulous formula development processes. Our advanced formulations are designed to enhance cellular function, supporting overall well-being and longevity through targeted nutritional support. At BONTAC, we recognize that every person's metabolism-boosting journey is unique, and we strive to provide a diverse range of products that cater to a wide spectrum of needs and preferences. Whether it's supporting energy production, promoting efficient nutrient utilization, or enhancing metabolism-boosting flexibility, our comprehensive lineup of metabolism-boosting products is designed to empower individuals to take control of their metabolism-boosting well-being. Unlocking the Benefits of Cellular Health Supplements BONTAC raw materials for cellular health supplements are carefully crafted to strengthen cellular resilience, boost energy metabolism, and promote optimal cell function. By incorporating the latest scientific advancements, our products can fortify the body at the cellular level, offering a comprehensive approach to enhancing health and vitality. Partnering with BONTAC for Cellular Wellness Solutions When businesses partner with BONTAC, they gain access to tailored strategies for cellular health, backed by our expertise in the field. Our commitment to technical innovation ensures that our products continually evolve to meet the changing needs of our customers. Through collaboration with BONTAC, businesses can tap into our comprehensive business coverage and strengthen their health offerings with our advanced cellular health supplements. By choosing BONTAC's metabolism-boosting products, you are not only investing in your health but also aligning yourself with a company that is dedicated to advancing the field of metabolism-boosting science. With our unwavering commitment to quality, innovation, and customer satisfaction, we invite you to join us on this transformative journey towards optimal metabolism-boosting health and a vibrant, fulfilling life. Conclusion Embark on a transformative journey towards enhanced health and longevity with BONTAC state-of-the-art raw materials for cellular health supplements. Our commitment to excellence, technical support, and innovation sets us apart in the industry, ensuring that our products meet or even exceed the expectations of our partners and customers. Join us in optimizing cellular wellness and unlocking the full potential of health with BONTAC by your side. In conclusion, BONTAC advanced raw materials for cellular health supplements demonstrate our dedication to providing outstanding products that prioritize the well-being of our customers. If you require further information or assistance, please do not hesitate to reach out to our team.
NR: A Cardioprotective Booster via Glycolysis Activation in Low Insulin Settings
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, and the decreased NAD+ level is related to various pathologies such as cardiac diseases and ischemia-reperfusion (IR) Injury. Nicotinamide riboside (NR) now appears as optimal NAD+ precursor to mitigate acute cardiac IR injury. Notably, glycolysis activation may be one of the metabolic pathways underlying NR-mediated cardioprotection, and insulin can abrogate this protection. The merits of NR in protecting hearts By virtue of its high bioavailability, its safety in healthy adults or obese patients, and its superiority in efficient NAD+ elevation in humans as compared to other agents, NR has emerged as a leading NAD+ precursor candidate. Up till now, NR has been the only compound to retain cardioprotection in an in vivo IR model with clinically relevant anesthesia. About glycolysis Glycolysis is a metabolic process that allows organisms to obtain energy from glucose under aerobic and anaerobic conditions. During this process, glucose (C6H12O6) can converted into pyruvate (CH3COCOO + H). The released free energy is used to form the high-energy compounds adenosine triphosphate (ATP) and the reduced form of nicotinamide adenine dinucleotide (NADH). Glycolysis is the first step in the process of sugar metabolism in all living cells, which can be regulated to accommodate different metabolic needs. NR-mediated cardio-protection in relation to glycolysis and insulin NR treatment reduces IR-induced cardiac injury in the mouse heart. This protection is associated with glycolysis activation and abrogated in the presence of insulin. Concretely, NR increases NAD+ level, intermediates of glycolysis, pentose phosphate pathway (PPP) and tricarboxylic acid (TCA) cycle, and activates glycolysis in low glycolysis hearts (perfusion of glucose and fatty acid). When glycolysis is already fully activated by high plasma levels of insulin, NR’s protective effect against cardiac IR injury will be diminished or even absent. Conclusion The perioperative metabolic condition (e.g. fasting, low insulin versus non-fasting high insulin conditions) likely dictates the efficacy of NR treatment as therapy against cardiac IR injury. NR may especially offer protection through activation of glycolysis in conditions of low insulin, and its protective potential can diminish in the presence of insulin. Reference [1] Xiao Y, Phelp P, Wang Q, et al. Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol. Front Cardiovasc Med. 2021;8:712478. Published 2021 Aug 30. doi:10.3389/fcvm.2021.712478 [2] Xiao Y, Wang Q, Zhang H, et al. Insulin and glycolysis dependency of cardioprotection by nicotinamide riboside. Basic Res Cardiol. 2024;119(3):403-418. doi:10.1007/s00395-024-01042-4 BONTAC NR BONTAC is one of the few suppliers in China that can launch mass production of raw materials for NR, with self-owned factory and professional R&D team. Up till now, there are 170+ BONTAC patents. BONTAC provides one-stop service for customized products. Both malate and chloride salt forms of NR are available. By dirt of unique Bonpure seven-step purification technology and Bonzyme whole-enzymatic method, the product content and conversion rate can be maintained in a higher level. The purity of BONTAC NR can reach above 97%. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. BONTAC holds no responsibility for any claims, damages, losses, expenses, costs or liabilities resulting or arising directly or indirectly from your reliance on the information and material on this website.
Unearthing the safety and health benefits of natural sweetener steviol glycoside
Introduction Steviol glycosides are secondary metabolites obtained by extracting and isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness and a pure white powder color, which have been perceived as a natural sweetener/sugar substitution in food industry. In addition to this, steviol glycosides may be a high-quality medicinal resource. Chemical structure of major steviol glycosides The presence of a hydroxyl group in the C-13 position and a carboxyl group in the C-19 position is necessary for the sweet taste of these compounds. Herein, R1 and R2 are the major sweet glycosides, and the constituents attached to the base structure of steviol are glucose, rhamnose, and xylose sugar moieties. The composition of different carbohydrate fractions on R2 determines the sweetness and flavor quality of steviol glycosides. Application history of steviol glycosides Time Item ...... Paraguayans in South America use stevia’s dried leaves in brewing tea, spanning over 1,500 years. 1931 Two French chemists have isolated steviol glycosides, the components that render stevia distinctive sweet flavor. 1970s to 1980s Japan begins to use stevia as a sweetener for food and beverage, followed by Korea, China, Malaysia, Latin America and other countries. 2008 High-purity steviol glycosides and Reb A are approved as GRAS by US FDA. FSANZ approves the use of steviol glycosides. 2010 JECFA designates the usage of nine steviol glycosides (≥95% purity) in food and beverages. 2011 CODEX adopts steviol glycosides as a food additive and publishes a standard for food use. Following the safety review of steviol glycosides by EFSA, EU approves the use of steviol glycosides as a sweetener in 27 member states and limits the dosage. 2016 Canada conducts a safety evaluation on steviol glycosides and finds no safety risk, followed by the release of an announcement on the approval of multiple steviol glycosides as sweeteners in food. 2017 JECFA determines the specifications for steviol glycosides derived from the stevia plant. NHFPC (China) approves an expanded use of steviol glycosides. ...... ...... Health benefits of steviol glycosides In the food industry, steviol glycosides have intensively applied as sweeteners by virtue of unique sweet and refreshing taste, which can be used to: * Enhance the softness and moisture of baking products * Increase the aroma of the wine and reduce viscosity * Improve flavor, extend shelf life and reduce cost * Reduce the sweetness brought by sucrose * Develop low sugar diary products Beyond their value as sweeteners, steviol glycosides possess therapeutic effects against several diseases such as cancer, diabetes mellitus, hypertension, inflammation, cystic fibrosis, obesity and tooth decay. Safety and toxicological evaluation of steviol glycosides Safety of steviol glycosides has been confirmed in numerous toxicological studies including acute and subacute toxicity, reproductive toxicity, genotoxicity and carcinogenicity investigations. Acceptable Daily Intake (ADI) of 0-2 mg/kg body weight/day has been accepted for steviol glycosides by the Joint FAO/WHO Expert Committee on Food Additives. Conclusion Steviol glycosides found in Stevia are not teratogenic, mutagenic or carcinogenic, showing no acute and subacute toxicity under recommend AD. Its application is not merely limited to sweeteners/sugar substitutions, and its promising value is awaited to be further unearthed. Reference [1] Momtazi-Borojeni AA, Esmaeili SA, Abdollahi E, Sahebkar A. A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana. Curr Pharm Des. 2017;23(11):1616-1622. doi:10.2174/1381612822666161021142835 [2] Huang C, Wang Y, Zhou C, et al. Properties, extraction and purification technologies of Stevia rebaudiana steviol glycosides: A review. Food Chem. 2024;453:139622. doi:10.1016/j.foodchem.2024.139622 BONTAC Stevioside RD BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 180 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of Stevioside Reb-D. BONTAC possesses the international application and authorized patents on Stevioside Reb-D (US11312948B2 & ZL2018800019752), where the product quality (purity and stability) can be better ensured. One-stop service for customized product solution is available in BONTAC. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.