Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
BONTAC NMNH product features and advantages
1. "Bonzyme" Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder.
2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability.
3. Exclusive “Bonpure” seven-step purification technology, high purity (up to 99%) and stability of production of NMNH powder
4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder
5. Provide one-stop product solution customization service
NADH powder manufacturing method
The main methods of NMNH powder preparation include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme becomes the mainstream method owing to the advantages of pollution free, high level of purity and
NMNH is more potent than NMN
When applied to cultured cells, the NMNH is shown to be more efficient than NMN as it was able to “significantly increase NAD+ at a ten times lower concentration (5 µM) than that needed for NMN”. Moreover, NMNH shows to be more effective , as at 500 µM concentration, it achieved “an almost 10-fold increase in the NAD+ concentration, while NMN was only able to double NAD+ content in these cells, even at 1 mM concentration.”.
Interestingly, NMNH also appears to act quicker and has a longer-lasting effect compared to NMN. According to the authors, NMNH induces a “significant increase in NAD+ levels within 15 minutes”, and “NAD+ steadily increased for up to 6 hours and remained stable for 24 hours, while NMN reached its plateau after only 1 hour, most likely because the NMN recycling pathways to NAD+ had already become saturated.”.
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Frequently Asked Question
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NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
Nicotinamide adenine dinucleotide (NAD+ ) homeostasis is constantly compromised due to degradation by NAD+ -dependent enzymes. NAD+ replenishment by supplementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can alleviate this imbalance. However, NMN and NR are limited by their mild effect on the cellular NAD+ pool and the need of high doses. Here, we report a synthesis method of a reduced form of NMN (NMNH), and identify this molecule as a new NAD+ precursor for the first time. We show that NMNH increases NAD+ levels to a much higher extent and faster than NMN or NR, and that it is metabolized through a different, NRK and NAMPT-independent, pathway. We also demonstrate that NMNH reduces damage and accelerates repair in renal tubular epithelial cells upon hypoxia/reoxygenation injury. Finally, we find that NMNH administration in mice causes a rapid and sustained NAD+ surge in whole blood, which is accompanied by increased NAD+ levels in liver, kidney, muscle, brain, brown adipose tissue, and heart, but not in white adipose tissue. Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.
First, inspect the factory. After some screening, NMNH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NMNH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMNH cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NMNH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
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Mitigation of TOCP-induced Oocyte Damage by Replenishing NMN
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry and agriculture in the last century. However, it is subsequently banned due to the increasing understanding of its toxicity. In the 21st century, TOCP comes back into the limelight as the aviation industry springs up. This research uncovers the adverse effects of TOCP on the reproductive system. Notably, nicotinamide mononucleotide (NMN), a crucial intermediate in the generation of NAD+, may serve as a therapeutic intervention to attenuate the oocyte damage caused by TOCP. About TOCP TOCP, a classic aromatic organophosphate ester, generally functions as flame retardant, plasticizer, lubricant, and jet fuel additive due to its chemical and thermal stability. At room temperature, TOCP is an odorless, yellowish transparent liquid. It is insoluble in water, but soluble in organic solvents such as alcohol, ether and benzene. In addition to its use in aviation industry, TOCP is currently applied in the manufacturing of construction materials such as plastics, furniture, textiles, printed circuit boards, and insulation. The negative roles of TOCP in oocytes Through the analyses of germinal vesicle breakdown (GVBD) and polar body extrusion (PBE), it is discovered that TOCP impedes the maturation process of oocyte meiotic division, suppressing the reinitiation of oocytes and the final extrusion of the first polar body. Remarkably, maturation of oocytes is deemed as a critical prerequisite for successful fertilization and subsequent embryonic development. Besides, it triggers disturbances in the cytoskeleton of oocytes and affects the distribution and functionality of mitochondria. Furthermore, exposure to TOCP alters the genes related to histone modification in oocytes, as manifested by the elevated levels of histone methylation at H3K9me3 and H3K27me3. The reversing effects of NMN on TOCP in oocytes Replenishing NMN partially restores the spindle/chromosome structure as well as the attachment of microtubules to centromeres, and stabilizes the distribution of actin filaments, thereby maintaining chromosomal integrity and supporting the nuclear maturation process of oocytes. Meanwhile, NMN is also effective in rescuing mitochondrial dysfunction induced by TOCP, which restores membrane potential and ATP levels, reduces excessive ROS production, prevents DNA damage, and hinders cell apoptosis as well as epigenetic alterations. Conclusion Nicotinamide mononucleotide maintains cytoskeletal stability and fortifies mitochondrial function to mitigate oocyte damage induced by TOCP, signifying its potential application value in refining reproductive therapeutic strategies. Reference Meng F, Zhang Y, Du J, et al. Nicotinamide mononucleotide maintains cytoskeletal stability and fortifies mitochondrial function to mitigate oocyte damage induced by Triocresyl phosphate. Ecotoxicol Environ Saf. 2024;275:116264. doi:10.1016/j.ecoenv.2024.116264 BONTAC NMN BONTAC is the pioneer of NMN industry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
What is Pure NMN Powder? Its Potential Benefits and 4 Basic Applications
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN powder. NMN powder—Nicotinamide Mononucleotide—is a derivative of Vitamin B3 (Niacin). It is a potent anti-aging molecule that helps counter the effects of growing age. Moreover, it increases overall body energy, reducing tiredness. In simpler words, NMN is a total game changer in age vs. health combat! So, what is NMN powder, and how can you use it to maximize your health? Read on to find out all. What is Beta-Nicotinamide Mononucleotide (NMN)? NMN, or Beta-Nicotinamide Mononucleotide, is a precursor molecule of NAD+ (Nicotinamide Adenine Dinucleotide) in the body. Research has shown that NAD+ combines with particular molecules called sirtuins to enhance longevity, which is achieved by converting food molecules into energy packets that are later used to carry out bodily functions[1]. NAD+ is also a crucial component of the body's age cycle. It regulates cellular health by acting on anti-aging genes and turning them on and off to regulate metabolism. However, NAD+ only has limited body stores. Therefore, a decrease in NAD+ leads to aging. Pure NMN powder prevents this decline by complementing the NAD+ deficiency, ultimately leading to a better life expectancy. Potential Benefits of Pure NMN Powder David Sinclair, a Harvard professor of genetics, has been working on the benefits of pure NMN powder for aging for decades. According to David Sinclair's NMN research and existing studies, the role of NMN is that of an activator. Based on this role, NMN provides the following benefits to the body: 1. May Boost NAD+ Levels in the Body Acting as a moderator, NMN converts NAD into activated forms. It helps increase energy production in the body, making you feel energized. The activated NAD+ then performs vital functions of the body, like: * Reduced inflammation * Stress resistance * Maintaining circadian rhythms * DNA repairs * Boosting energy metabolism * Improving athletic performance 2. May Improve Metabolic Health and General Wellness Pure NMN powder raises NAD+ levels throughout your body. With a healthy diet and lifestyle, it may be helpful for old-age problems and chronic diseases, improving overall health. These might include: * Protect the cardiovascular and cerebrovascular * Prevent cancer * Regulates blood sugar * Help with weight loss * Improve sleeping * Prevent neurodegenerative diseases * Auxiliary hypolipidemic * Auxiliary hypoglycemic * Hearing and vision protectionPromote alcohol metabolism, hangover and protect the liver 3. May Offer Anti-Aging Effects NAD+ is a key player in our body's energy production and DNA repair processes. Pure NMN powder holds promise as a potential anti-aging agent by bolstering intracellular NAD+ levels. NMN may exert further anti-aging effects by enhancing mitochondrial function and potentially lengthening telomeres. Though the precise mechanisms underlying NMN's anti-aging properties are still under investigation, its potential to support cellular health and longevity by utilizing pure NMN powders effectively. Top 4 Applications of Pure NMN Powder Pure NMN can stand as a versatile supplement and is easily incorporated into our daily lives. Common dosage forms of NMN products may include capsules, tablets, granules, powder, candies, and beverages. With its potential benefits, pure NMN powder finds utility across multiple fields: 1. Health Care Products NMN supplements are used to treat a variety of health conditions. It is touted for its anti-aging properties and potential benefits for metabolism and overall health. Whether it's being used in an anti-aging supplement or a sleep aid, pure NMN powder holds promise for potentially slowing the effects of aging or enhancing sleep quality. 2. Cosmetic Raw Materials NMN also improves skin metabolism by boosting NAD+ production. It further helps to fight off skin problems, increases new regeneration, and creates a glow from within. It is widely used in some anti-aging skincare formulations and for moisturizing and repairing cosmetic products. 3. Functional Food Additives Pure NMN powder is also a functional food additive. It enhances mental concentration and physical vigor, particularly in situations demanding sustained energy. It is frequently found in energy drinks and various health foods like energy bars, gummies, and cereals. 4. Animal Health Last but not least, animal health also benefits from NMN powder. When used in medical treatments and animal feeds, they help boost overall physiological functions and promote vitality. It helps increase the overall life span of animals. BONTAC's Premium Quality Wholesale Pure NMN Powder The efficacy of NMN depends on the quality and purity of the product. Thus, always use high-quality and original NMN products for ideal results. BONTAC is a well-known brand among bio-engineered NMN suppliers. We are the raw material supplier for the NMN study of David Sinclair's team. At the same time, we are also the sole provider of raw materials for clinical trials in many well-known institutions in Japan and the United States. We are known for our premium-quality, pure NMN powder. Our NMN powder is white with no visible impurities. It has a unique smell and a balanced pH (3.0-4.0), offering up to 99.5% purity. Our product advantages include: * 21 domestic and international NMN patents and multiple international certifications * Exclusive “Bonpure” seven-step purification technology, high purity (up to 99.9%) and stability * “Bonzyme” whole-enzymatic method, no harmful solvent residues, environmental-friendly * Multiple in vivo studies show that BONTAC NMN is safe and effective * One-stop customized product solution * Self-owned factories, high quality and stable supply of products All these leading industrial technologies and advantages make BONTAC the best NMN supplier in the biotech industry. IFrame Source: https://www.youtube.com/watch?v=FYkkJfuwttg Final Thoughts NMN has great potential for skin, heart, gut, and aging concerns. When you choose BONTAC, expect nothing but pure NMN powder of unparalleled purity and quality. BONTAC also offers wholesale purchases of NMN powder bulk and a one-stop solution for large businesses. Contact us and get the latest information on product availability. References [1] Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821238/ (Accessed: 6 May 2024)
Rh2 and Ca(OH)2 Combo: Promising Treatment for Root Canal Infections
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus (E.) faecalis, a pathogenic bacterium that has extremely high tolerance to the most often used root canal dressing calcium hydroxide (Ca(OH)2). Ginsenoside Rh2, a Chinese herbal extract, has been affirmed to possess anti-microbial properties and synergistic activities. The combination of Rh2 with Ca(OH)2 appears to be a potential alternative to root canal treatment. About E. faecalis E. faecalis is a facultative anaerobic gram-positive bacterium, which has been deemed as the main pathogenic factor of refractory periapical infections. This bacterium can survive for a long time by forming a biofilm with very strong adhesion in a hostile environment, and is resistant to the mechanical cleaning and the medications for root canal disinfection. The synergistic antibacterial activities of Rh2 and Ca(OH)2 against E. faecalis. Rh2 has the potential to enhance the ability of Ca(OH)2 to eradicate E. faecalis and its biofilms in root canals by disrupting the cell membrane and inhibiting the proton transport system on the bacterial surface. The removal of mature bioflims by Rh2 is mainly achieved by removing extracellular polysaccharides and inhibiting bacterial activity. Specifically, Rh2 significantly inhibits H+/K+-ATPase activity of E. faecalis with increasing drug concentration, thus inhibiting the exocytosis of −OH from Ca(OH)2. Strikingly, neither Rh2 nor its combination with Ca(OH)2 shows toxicity to L929 cells at effective antimicrobial activity concentrations. Conclusion Rh2 is a phytochemical substance, with the merits of low cytotoxicity, high efficiency and reproducibility, stable quality, and enhancement of the efficacy of antagonistic drugs. Ginsenoside Rh2 and Ca(OH)2 exert a synergistic antibacterial effect on E. faecalis, providing novel insights into the development of root canal treatment drugs. Reference Liu C, Li Y, Li Y, Li Z, Han G. Synergistic antibacterial effect of ginsenoside Rh2 and Ca(OH)2 on Enterococcus faecalis. Odontology. Published online May 19, 2024. doi:10.1007/s10266-024-00951-z BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.