BONTAC | A brief introduction to nadh manufacturer

BONTAC | A brief introduction to nadh manufacturer

In general, there are three main manufacture methods for NADH preparation utilized by NADH manufacturers in the world such as chemical or enzymatic synthesis, and fermentation biosynthesis. And at present, the NADH manufacturers are located worldwide including China, America, Japan and German.
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Advantages of NMNH

NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service

Advantages of NADH

NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service

Advantages of NAD

NAD:  1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products

Advantages of MNM

NMN:  1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity(up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University

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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.

As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.

In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.

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BONTAC NADH product features and advantages

1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder

2、Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NADH powder

3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder  

4、Provide one-stop product solution customization service

BONTAC NADH product features and advantages

NADH powder efficacy in health

1.Improved energy levels
Not only does NADH act as an important coenzyme in aerobic respiration, the [H] of NADH also carries a large amount of energy. Studies have demonstrated that extracellular use of NADH promotes increased intracellular ATP levels, suggesting that NADH penetrates cell membranes and elevates intracellular energy levels. On a macro level, exogenous supplementation of NADH helps to restore energy and enhance appetite. The increase in energy levels in the brain also helps to improve mental performance and sleep quality. NADH has been used overseas to improve chronic fatigue syndrome, increase exercise endurance, jet lag and other areas.
2.Cellular protection
NADH is a strong antioxidant that naturally occurs in cells and reacts with free radicals to inhibit lipid peroxidation, protecting mitochondrial membranes and mitochondrial function. It has been found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise and ischemia, thus protecting vascular endothelial cells, hepatocytes, cardiomyocytes, fibroblasts and neurons. Therefore, injectable or oral NADH is used clinically to improve cardiovascular and cerebrovascular diseases, and as an adjunct to cancer radiotherapy. Topical NADH has been shown to be effective in the treatment of rosacea and contact dermatitis.
3.Promotion of neurotransmitter production
Studies have shown that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal that is essential for short-term memory, involuntary movements, muscle tone and spontaneous physical responses. It also mediates the release of growth hormone and determines muscle movement. Without sufficient dopamine, muscles become stiff. Parkinson's disease, for example, is caused in part by a disruption of dopamine synthesis in brain cells. Preliminary clinical data suggest that NADH can help improve the symptoms of Parkinson's disease [9]. NADH also promotes the biosynthesis of norepinephrine and serotonin, showing good potential for use in the relief of depression and Alzheimer's disease.

NADH powder efficacy in health

NADH manufacturing method

The main methods of NADH powder preparation from worldwide NADH manufacturers include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme become the mainstream method owing to the advantages of pollution free, high level of purity and stability.  

NADH manufacturing method
User Reviews

What users say about BONTAC

BONTAC is a reliable partner that we have been working with for many years. The purity of their coenzyme is very high. Their COA can achieve relatively high test results.

Front

I discovered BONTAC in 2014 because David's article in cell about NAD and NMN related showed that he used BONTAC's NMN for his experimental material. Then we found them in China. After so many years of cooperation, I think it is a very good company.

Hanks

I think green, healthy and high purity are the advantages of BONTAC's products compared with others. I still work with them to this day.

Phillip

In 2017, we chose BONTAC's coenzyme, during which our team encountered many technical problems and consulted their technical team, which were able to give us good solutions. Their products are shipped very fast and they work more efficiently.

Gobbs
Frequently Asked Question

Do you have any question?

1.    Prevention and treatment of viral-induced inflammatory storms
Scientists have found after extensive research that neo-coronavirus has a mechanism similar to SARS virus to activate inflammatory vesicles NLRP3. and the activation of NLRP3 produces more inflammatory factors, generating excessive inflammation and thus triggering a deadly cytokine storm. This problem can be well addressed by NAD+, which inhibits the activity of NF-κB inflammatory pathway and NLRP3 inflammasome by increasing the activity of sirtuins (SIRT1, SIRT2 and SIRT3), thus preventing cytokine storm caused by excessive inflammation. Therefore, Sinclair and other scientists believe that increasing the concentration of NAD+ may play an important role in the prevention and treatment of neocoronavirus and other viral infections.
2.    Restoration of virus-induced metabolic disorders
NAD+ is an essential coenzyme for many cellular energy metabolic pathways, present in every cell of the body, involved in thousands of reactions, and an important player in maintaining cellular viability. In the COVID-19 infection model, NAD+ and NMN supplementation was found to be effective in alleviating cell death and protecting the lung.

The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes

First, inspect the factory. After some screening, NADH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NADH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NADH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.

Our updates and blog posts

BONTAC in FHE 2024: Innovation of Raw Materials in Biosynthesis

Introduction On Feb 25-29, 2024, BONTAC was invited to 2024 Boao Healthy Food Science Conference & Exposition (FHE 2024) and made a discussion with the industry elites on the innovation of science and technology as well as the trend towards industry development in the health food area. Conference profile There are 15 academicians, 300 report experts, and over 2000 delegates from around the world gathering around the conference. More than 40 professional forums are planned in FHE 2024, attracting the active participation of domestic and foreign industry leaders such as Danone, Nestle and Pepsi. BONTAC star products in FHE 2024 By dirt of its innovative technology and strong R&D strength in the field of green biosynthesis, BONTAC stands out from the crowd. To date, there are over 170 global patents by BONTAC. BONTAC star products, including NMN, NADH and ginsenoside Rh2/Rg3, are present in FHE 2024, which are highly recognized by many brand owners. Many attendees are attracted to learn more and negotiate with BONTAC for further cooperation. Notably, Professor Chen Junshi from Chinese Academy of Engineering visited the booth of BONTAC, gave guidance to the team of BONTAC and highly praised the innovative achievements in the field of biosynthesis. Facilitating the development of high-quality health food via innovation of science and technology From the traditional healthcare with herbs to modern precision nutrition, health has always been the focus of people. With the progress of science and technology, the development of new functional nutrients has gradually relied on the support of technical innovation. In various niche areas of health, NMN has emerged as an essential force in health industry by leverage of its unique science base and broad application prospect. Mounting scientific research and clinical practice have attested the obvious efficacy of NMN in promoting the immunity, improving the cardiovascular health, and alleviating the fatigue. Conclusion FHE 2024 is the first domestic platform for the communication of scientific evidence on health beneficial food. In the future, BONTAC will continue to provide comprehensive solutions for anti-aging series products including coenzyme and natural extracts, and facilitate the development of high-quality food via innovation of science and technology. About BONTAC BONTAC has been dedicated to the green biosynthesis for 12 years, with the intention of creating a better life for human beings. Up till now, there are 173 patents by BONTAC. As the pioneer of NMN industry, BONTAC is the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”.

Invitation from BONTAC to VitaFoods Europe 2024

On May 14th~16th 2024, the VitaFoods Europe is going to be held at the Palexpo exhibition center, Geneva, Switzerland. It is estimated that over 20,000 visitors from over 160 countries and 1,100 exhibitors will participate in this big event this year. BONTAC sincerely invites you to visit Booth No. B172. Our patent-grade raw materials for coenzymes, natural products, sugar substitutes and dietary supplements will be there. Looking forward to your coming! About VitaFoods Europe Vitafoods Europe has consistently served as a hub for the international nutraceutical industry since its establishment in 1997. Each year, it draws together a diverse array of professionals and companies, initiating critical conversations, enriching their understanding of the most pressing issues in the health and nutrition industry, and creating a dynamic environment for collaboration and trade. The Palexpo exhibition center in Geneva covers an area of 70,000 m2. The city of Geneva has played a significant role in the unfolding saga of VitaFoods Europe for a period spanning more than two decades. After 26 years in Switzerland, Vitafoods Europe will relocate to Barcelona in 2025. This year may be the last time to celebrate this grand event in Switzerland before relocation. BONTAC profile Bontac Bio-Engineering (Shenzhen) Co., Ltd. (also referred to as BONTAC) is a high-tech enterprise established in July 2012, with self-owned factories and more than 170 invention patents. BONTAC integrates R&D, production and sales. There are six major series of product in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates. By virtue of the first whole-enzyme catalysis technology in China, BONTAC takes the industry lead in its niche field of coenzyme. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields.

Application Foreground of Stevioside in Aquaculture

Introduction Lead (Pb) contamination in aquatic environments poses a significant threat to the health and well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics and probiotics as food ingredients, due to the fact that they can mitigate cadmium and Pb toxicity in animals. Intriguingly, the natural sweeter stevioside, which is commonly utilized as sugar substitutes in a variety of food and beverage products, can be deemed as a prebiotic that enhances the gastrointestinal microflora by increasing beneficial bacteria and mitigates the adverse effects of Pb toxicity in thinlip mullet juveniles, showing favorable application foreground in enhancing fish health and improving aquaculture management practices. Hazards of Pb to thinlip mullet juveniles The thinlip mullet is a key component of the aquatic food chain, which is highly susceptible to the adverse effects of environmental contaminants, including Pb. Exposure to Pb can lead to impaired growth, altered biochemical profiles, oxidative stress and compromised immune response in thinlip mullet juveniles. Apart from these, hepatic damage is observed after Pb exposure, as manifested by increases in serum ALT and AST levels as well as adverse effects such as vascular dilatation of the central vein, vacuolation of hepatocytes, pyknosis of nuclei, and melanomacrophage alterations. Mitigating effect of stevioside against Pb-induced adverse effects Stevioside conspicuously improves the growth performance, regulates biochemical parameters (total protein, AST, and ALT) to a normal level as the control group and strengthens the antioxidant activity (SOD, CAT, and GPx) in thinlip mullet juveniles at a dose-dependent manner, while barely affecting their nutritional composition of whole-body tissues. In addition, Pb-induced immunosuppression is markedly counteracted by the addition of stevioside in the diet, as indicated by the enhanced immune response (lysozyme, bactericidal activity, NBT% and ACH50 level) and downregulation of genes associated with immune function (IL-10 and Hepcidin) in the liver of thinlip mullet juveniles exposed to Pb. Histopathologically, a gradual restoration of normal intestinal and hepatic architecture is seen following administration of stevioside, as evidenced by the improved structure of the intestine and the liver, with normal central vein and melanomacrophage aggregation. Conclusion Stevioside can mitigate lead toxicity in thinlip mullet juveniles, making great impacts upon their growth, metabolism, and immune function, providing new insight into alleviating the effects of environmentally toxic substances on aquatic organisms. Reference Shehata AI, Shahin SA, Elmaghraby AM, et al. Stevioside mitigates lead toxicity in thinlip mullet juveniles: Impacts on growth, metabolism, and immune function. Aquat Toxicol. Published online April 11, 2024. doi:10.1016/j.aquatox.2024.106910 BONTAC Stevioside RD BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of Stevioside Reb-D. BONTAC possesses the international application and authorized patents on Stevioside Reb-D (US11312948B2 & ZL2018800019752), where the product quality (purity and stability) can be better ensured. One-stop service for customized product solution is available in BONTAC. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.

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