Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
What NMN Supplements Do?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
However, these studies were small, and NMN has not been shown to be effective in clinical trials, so further research is needed to determine the effectiveness of NMN supplements.
What diseases can NMN supplements treat?
NMN (Nicotinamide Mononucleotide) is a substance similar to vitamin B3, which can produce NAD+ (a key metabolic intermediate) in the body. Therefore, studies have shown that NMN may help improve aging-related health issues such as metabolism, immunity, cell repair, brain health, and more.
Currently, NMN supplements are mainly used to treat the following diseases:
Aging-related metabolic disorders such as diabetes, obesity, high cholesterol, etc.
Aging-related neurodegenerative diseases, such as Alzheimer's disease.
Aging-associated immune decline.
Aging-related cardiovascular disease.
What are the purposes of NMN supplements?
NMN supplements are mainly used to increase NAD+ levels to improve metabolic diseases and slow down the aging process.
Improve metabolic diseases: Studies have shown that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity.
Delay the aging process: NMN can increase the vitality of cells, improve the metabolic process of cells, and delay the aging process.
Protect DNA: NAD+ is an important metabolic substance in cells and participates in various biological processes such as cellular energy metabolism and DNA repair. Supplementing NMN can increase NAD+ levels and protect DNA.
Improves Athletic Capacity: NMN has been shown to improve athletic performance and increase fat burning ability
Improve neurodegenerative diseases: Studies have shown that NMN can improve neurodegenerative diseases, such as Alzheimer's disease
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Frequently Asked Question
Do you have any question?
NMN supplements may cause side effects such as upset stomach, diarrhea, and nausea. There is also research showing that NMN supplements may affect insulin sensitivity and insulin levels, so people with diabetes should consult their doctor before taking them.
NMN supplements have not yet undergone large-scale clinical trials to verify their effectiveness. Currently, research on NMN supplements is mainly focused on animal and in vitro experiments. These studies show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process.
The long-term health effects of NMN supplementation are not well studied. Existing studies mainly focus on animal and in vitro experiments, which show that NMN can improve the symptoms of metabolic diseases such as diabetes, fatty liver and obesity, and can delay the aging process. However, the results of these studies do not represent the long-term effects of NMN on human health.
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Innovating Solutions: BONTAC's Biotechnology Product Offerings
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving landscape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation and progress. Our commitment to excellence is demonstrated through our diverse range of exceptional products, unwavering technical support, continuous pursuit of technical innovation, and extensive business coverage. At BONTAC, we are dedicated to empowering businesses across various industries with our pioneering biotechnology solutions. Cutting-Edge Biotechnology Products by BONTAC Discover the depth and breadth of BONTAC's unparalleled biotechnology product range, designed to address a wide array of industry needs. From advanced research tools to revolutionary bio-based materials, each product is a testament to our dedication to pushing the boundaries of biotechnological advancement. Our products embody the latest scientific insights and technological breakthroughs, ensuring that they meet the highest standards of quality and performance. At the heart of our offerings lies a cutting-edge portfolio of biotechnology products that encompass a wide range of applications. Whether you are engaged in advanced scientific research or seeking revolutionary bio-based materials, BONTAC's product range is designed to cater to diverse industry needs. Each product we offer is a testament to our relentless dedication to pushing the boundaries of biotechnological advancement. Features and Benefits of BONTAC's Biotechnology Products Explore the unique characteristics and benefits that set BONTAC's biotechnology solutions apart in the market. Our products are meticulously crafted to enhance efficiency, sustainability, and productivity in various applications. Customers who have embraced BONTAC's biotechnology offerings have experienced transformative results, showcasing the tangible impact of our products on their operations and outcomes. We understand that the success of businesses across industries hinges on access to the latest tools and technologies. That's why BONTAC's biotechnology products embody the latest scientific insights and technological breakthroughs. Our team of experts combines deep domain knowledge with rigorous research and development efforts to ensure that our products meet the highest standards of quality, reliability, and performance. Collaborating with BONTAC for Biotechnology Excellence Partnering with BONTAC opens doors to tailored biotechnology solutions that align with your specific business requirements. Our team of experts provides unparalleled technical support to guide you through product selection, integration, and optimization. By leveraging BONTAC's technical expertise and innovative product portfolio, businesses can drive forward their biotechnology initiatives with confidence and success. Long-term partnerships with BONTAC foster a culture of continuous innovation and mutual growth. Conclusion In conclusion, BONTAC is your trusted partner in navigating the dynamic world of biotechnology products. Embrace our excellent products, technical support, and commitment to technical innovation to elevate your biotechnology endeavors. With BONTAC by your side, you can harness the power of cutting-edge biotechnology solutions to drive your business forward and shape a brighter future.
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthroughs in the field. Our commitment to excellence is demonstrated through our pioneering research initiatives, cutting-edge products, and unwavering focus on technical innovation. At BONTAC, we continuously strive to push the boundaries of biotechnical research to revolutionize industries and improve life. Advancing Biotechnical Research at BONTAC Within BONTAC's research laboratories, a culture of exploration and discovery fuels our quest for innovative solutions in biotechnical research. Our team of experts combines scientific expertise with creative insights to tackle complex challenges and uncover new opportunities. BONTAC's investment in state-of-the-art technology and research facilities underscores our dedication to advancing biotechnical research for the betterment of society. Impactful Applications of Biotechnical Research The fruits of BONTAC's biotechnical research are evident in our array of products that harness the power of scientific insights and technological advancements. These products are the result of meticulous research and development processes aimed at enhancing various sectors such as healthcare, agriculture, and environmental sustainability. From novel treatment options to sustainable agricultural solutions, BONTAC's biotechnical innovations are reshaping industries and driving positive change. At BONTAC, we understand that cellular rejuvenation is not a one-size-fits-all approach. Every individual possesses unique cellular characteristics and experiences distinct environmental factors that influence their overall well-being. That is why we take a personalized approach to cellular rejuvenation, tailoring our solutions to meet the specific needs of each individual. By recognizing the diversity of our customers and their unique cellular profiles, we aim to provide targeted interventions that optimize cellular health and unlock the potential for enhanced vitality. Collaboration and Partnerships in Biotechnical Research Collaboration lies at the heart of BONTAC's approach to biotechnical research, as we recognize the value of partnering with industry leaders and experts to accelerate innovation. By fostering strategic alliances and engaging with key stakeholders, BONTAC creates a network of excellence that fosters collaboration, knowledge exchange, and collective progress in biotechnical research. Altogether, we aim to shape the future of biotechnical innovation and deliver impactful solutions to global challenges. Conclusion In conclusion, BONTAC's dedication to pioneering discoveries in biotechnical research sets us apart as a leader in the field. Our focus on excellent products, robust technical support, and a commitment to technical innovation propels us toward groundbreaking advances that benefit society as a whole. Join us on this exciting journey as we continue to explore new frontiers in biotechnical research, where innovation meets excellence.
Rg3-PLGA@TMVs May Be the Candidates for Potential Inclusion in Cancer Therapy
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy and low toxicity when used in tumor treatment. They have unique advantages in treating diseases compared with chemotherapeutic drugs due to their multi-component and multi-target effects. Strikingly, ginsenoside Rg3-loaded PLGA nanoparticles (Rg3-PLGA) coated with the membrane of tumor cell-derived microvesicles (Rg3-PLGA@TMVs), which is a nanoformulation of the natural product ginsenoside Rg3, have a significant role in the treatment of breast cancer when combined with the chemotherapeutic drug doxorubicin (DOX). Pharmacological roles of ginseng Rg3 in traditional Chinese medicine Ginseng Rg3, a tetracyclic triterpenoid saponin, is one of the main active component of ginseng. Ginseng has been regarded as one of the most valuable medicinal plants in Chinese traditional medicine for thousands of years, which is known as "the king of all tonic”. This perennial herb possesses the multiple pharmaceutical functions such as tonifying the vital energy, restoring the pulse and stabilizing the loss of vitality, invigorating spleen and benefiting lung, generating saliva or body fluid to quench thirst, as well as tranquilizing the mind and promoting the intelligence. The construction of Rg3-PLGA@TMVs Ginsenoside Rg3 is first encapsulated into PLGA nanoparticles using the nanoprecipitation method, followed by the extrusion-based coating of the TMV membrane onto Rg3-PLGA. This strategy combines the therapeutic properties of Rg3 with the precise delivery and sustained release capabilities of PLGA nanoparticles, further enhanced by the homologous targeting properties of TMVs. Anti-tumor effect and bio-safety of Rg3-PLGA@TMVs in 4T1 breast cancer Rg3-PLGA@TMVs induce robust anti-tumor immunity, recover the body weight loss caused by DOX in 4T1 breast cancer and overtly improve the anti-tumor effect of DOX, showing good stability and drug loading capability. These anti-tumor effects are chiefly realized by reducing phagocytic activity and acid phosphatase (ACP) levels, promoting the maturation of bone marrow-derived dendritic cells in vitro, and elevating the population of cytotoxic T lymphocytes (CD3+CD8+) and helper T cells (CD3+CD4+) in vivo. Importantly, this nanoformulation has minimal side effects and favorable biocompatibility, which can relieve the organ toxicity caused by DOX, especially the cardiac side effects. The administration of DOX and Rg3-PLGA@TMVs does not result in statistically significant changes in white blood cell (WBC) count and renal functional indicators, such as CREA and urea, nor in hepatic functional indicators, including AST and ALT. Conclusion Rg3-PLGA@TMVs achieve the co-delivery of antigens and adjuvants, which not only potentiate the anti-tumor effects, but also significantly alleviate the systemic toxicity caused by chemotherapeutic drugs, improving the overall health status of patients undergoing chemotherapy. Reference [1] Liu XR, Zhang KF, Li X, et al. Research progress on antitumor nanoscale drug delivery system of ginsenoside Rg3 [J]. Chin Trad Herb Drugs. 2023,54(22):7577-7587. DOI: 10.7501/j.issn.0253-2670.2023.22.034 [2]Zhang S, Zheng B, Wei Y, et al. Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity [J]. Biomater Sci. Published online April 10, 2024. DOI:10.1039/d4bm00159a BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.