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Delving into the Function of Ginsenoside Rh2 in the Develpoment of Breast Cancer
Delving into the Function of Ginsenoside Rh2 in the Develpoment of Breast Cancer

1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the

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The Significance of NAD+ in Intestinal Senescence Caused by Elevated mtDNA Mutations
The Significance of NAD+ in Intestinal Senescence Caused by Elevated mtDNA Mutations

1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis and the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N

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The Immuno-Enhancing Effect of Rh2-L on Double Emulsion Adjuvant Against Foot-and-Mouth Disease
The Immuno-Enhancing Effect of Rh2-L on Double Emulsion Adjuvant Against Foot-and-Mouth Disease

1. Introduction At present, vaccine is the preferred option for the prevention of foot-and-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi

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NMN Administration: a Novel Therapeutic Direction for Sepsis-induced Acute Lung Injury
NMN Administration: a Novel Therapeutic Direction for Sepsis-induced Acute Lung Injury

1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, and tox

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Probing the Magic Role of NAD+ Metabolism-associated Genes in Gastric Cancer
Probing the Magic Role of NAD+ Metabolism-associated Genes in Gastric Cancer

  1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer and the fourth leading cause of cancer death across the world in 2020, with a significant

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A Scientific Method for Quantifying NMN in Biological Samples
A Scientific Method for Quantifying NMN in Biological Samples

1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is

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The Nuanced Role of NADPH in the Complex Landscape of Metabolic Disorders
The Nuanced Role of NADPH in the Complex Landscape of Metabolic Disorders

1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems and lipid synthesis, which links insulin

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Extraordinary Merits of Ultrasensitive ELISA with Thio-NAD Cycling in Determining Dengue NS1 Protein
Extraordinary Merits of Ultrasensitive ELISA with Thio-NAD Cycling in Determining Dengue NS1 Protein

1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi

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How to Reconcile the Axonal Degeneration Caused by NMN Accumulation with the Anti-ageing Effect of NMN
How to Reconcile the Axonal Degeneration Caused by NMN Accumulation with the Anti-ageing Effect of NMN

1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing

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