Global Breakthrough! Bontac : The World's First Patent for NMNH Crystal Form
Recently, China National Intellectual Property Administration officially granted Bontac Bioengineering (Shenzhen) Co., Ltd. a significant invention patent—“Amorphous Compound of Reduced β-Nicotinamide Mononucleotide Disodium Salt and its Preparation Method” (Patent No. ZL 202411650729.3).
This marks the world’s first successful development of amorphous crystal form technology for NMNH (β-nicotinamide mononucleotide, reduced form, disodium salt).
This milestone breakthrough represents not only another leap forward for Bontac in the core technology of coenzymes but also brings revolutionary progress to the global fields of anti-aging and health management, opening an entirely new chapter.
This marks the world’s first successful development of amorphous crystal form technology for NMNH (β-nicotinamide mononucleotide, reduced form, disodium salt).
This milestone breakthrough represents not only another leap forward for Bontac in the core technology of coenzymes but also brings revolutionary progress to the global fields of anti-aging and health management, opening an entirely new chapter.
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Bontac: The First Enterprise to Break the Global NMNH Crystal Form Bottleneck
NAD+ (Nicotinamide Adenine Dinucleotide) is a core coenzyme for human energy metabolism and cellular repair. Its levels decline with age and are closely linked to aging and various chronic diseases.
Traditional NAD intermediates (often referred to as “NAD supplements”) mainly exist in oxidized forms. NMNH, as the reduced precursor, offers higher bioactivity, enhancing NAD+ levels more efficiently while demonstrating antioxidant, anti-inflammatory, and metabolic improvement potentials. It is hailed as a “rising star in anti-aging.”
Traditional NAD intermediates (often referred to as “NAD supplements”) mainly exist in oxidized forms. NMNH, as the reduced precursor, offers higher bioactivity, enhancing NAD+ levels more efficiently while demonstrating antioxidant, anti-inflammatory, and metabolic improvement potentials. It is hailed as a “rising star in anti-aging.”
However, industrial-scale production of NMNH has long been hindered by two major challenges:
(1) Poor stability—it easily oxidizes and degrades, requiring stringent storage conditions;
(2) Complex processes—dependent on freeze-drying, which is costly and prone to moisture absorption and caking.
(1) Poor stability—it easily oxidizes and degrades, requiring stringent storage conditions;
(2) Complex processes—dependent on freeze-drying, which is costly and prone to moisture absorption and caking.
To overcome these technical bottlenecks, the Bontac biotechnology team spent years in R&D and ultimately resolved these global-level challenges, laying a solid foundation for the industrial application of NMNH.
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Bontac NMNH: New Process Outperforms Traditional Techniques Across the Board
The new patented technology adopts a “seed-induced precipitation method,” enabling efficient room-temperature NMNH production with the following key advantages:
(1) No freeze-drying required: The amorphous compound can be efficiently precipitated through conventional crystallization, making the process simpler, more cost-effective, and better suited for industrial-scale production.
(2) Superior stability: With moisture content below 5%, it can be stably stored for over three months at room temperature (20–30°C) in an airtight environment—far surpassing the traditional freeze-drying method.
(3) High purity and low hygroscopicity: With purity exceeding 99.5% and excellent flowability, it is well-suited for direct processing into tablets, capsules, and other dosage forms.
(2) Superior stability: With moisture content below 5%, it can be stably stored for over three months at room temperature (20–30°C) in an airtight environment—far surpassing the traditional freeze-drying method.
(3) High purity and low hygroscopicity: With purity exceeding 99.5% and excellent flowability, it is well-suited for direct processing into tablets, capsules, and other dosage forms.
Bontac’s Patented Process vs. Traditional Methods (Selected Measured Data Comparison):
These technical breakthroughs not only significantly improve the stability and operability of NMNH but also expand its application scope—delivering superior effects in anti-aging, energy metabolism, and neurological health. They also offer new possibilities for innovation in future health and medical products.
Moreover, Bontac’s NMNH raw material has demonstrated outstanding anti-aging performance in efficacy tests.
According to a recent report by a third-party authoritative agency, in a zebrafish aging model, the β-nicotinamide mononucleotide disodium salt sample provided by Bontac significantly elevated NAD+ levels. Fluorescence intensity increased by approximately 68% in the 120-minute treatment group compared to the control (0.38±0.04 vs. 0.64±0.06, P<0.05).
This result further validates the scientific basis and practical potential of NMNH in delaying aging.
Moreover, Bontac’s NMNH raw material has demonstrated outstanding anti-aging performance in efficacy tests.
According to a recent report by a third-party authoritative agency, in a zebrafish aging model, the β-nicotinamide mononucleotide disodium salt sample provided by Bontac significantly elevated NAD+ levels. Fluorescence intensity increased by approximately 68% in the 120-minute treatment group compared to the control (0.38±0.04 vs. 0.64±0.06, P<0.05).
This result further validates the scientific basis and practical potential of NMNH in delaying aging.
Bontac : Leading the Global Frontier of Coenzyme Science
As the pioneer in decoding life’s anti-aging mechanisms, Bontac has remained committed to innovation in enzyme catalysis technology and product optimization, aiming to provide high-quality health ingredients to global customers.
Looking ahead, Bontac will continue to push the frontiers of coenzyme technology, innovating health solutions to empower vitality through science—transforming every technical breakthrough into a new starting point for a healthier life!
Looking ahead, Bontac will continue to push the frontiers of coenzyme technology, innovating health solutions to empower vitality through science—transforming every technical breakthrough into a new starting point for a healthier life!
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